Detection of Papilledema and Pseudopapilledema in Children
Papilledema occurs when the optic nerves are swollen as a result of high pressure within the brain. This condition can be a sign of a serious neurologic disorder, such as a brain tumor. However, in children, pseudopapilledema is more common than papilledema. Pseudopapilledema is generally caused by structural changes in the eye and optic nerve, and is not a neurologic problem. Distinguishing between papilledema and pseudopapilledema is a common clinical dilemma for ophthalmologists. In children, diagnostic difficulties can lead to unnecessary and invasive testing, or failure to recognize a life-threatening condition. SAIL BioSP team is working with the Pediatric Optic Nerve Investigator Group (PONIG), a multicenter collaboration including pediatric neuro-ophthalmologists across the country, to leverage artificial intelligence (AI) to aid in distinguishing between the two diagnoses using ophthalmic imaging. Our first paper demonstrated that our AI model was superior to human experts in classifying fundus photographs of pediatric papilledema and pseudopapilledema. We aim to expand our model to include multimodal imaging, as well as data from additional sites.
Supported by NIH.
References
2024
Journal
Artificial Intelligence to Differentiate Pediatric Pseudopapilledema and True Papilledema on Fundus Photographs
Melinda Y Chang, Gena Heidary, Shannon Beres, Stacy L Pineles, Eric D Gaier, Ryan Gise, Mark Reid, Kleanthis Avramidis, Mohammad Rostami, Shrikanth Narayanan, others
@article{chang2024artificial,title={Artificial Intelligence to Differentiate Pediatric Pseudopapilledema and True Papilledema on Fundus Photographs},author={Chang, Melinda Y and Heidary, Gena and Beres, Shannon and Pineles, Stacy L and Gaier, Eric D and Gise, Ryan and Reid, Mark and Avramidis, Kleanthis and Rostami, Mohammad and Narayanan, Shrikanth and others},journal={Ophthalmology Science},pages={100496},year={2024},publisher={Elsevier},}
2022
ICIP 2022
Automating Detection of Papilledema in Pediatric Fundus Images with Explainable Machine Learning
Kleanthis Avramidis, Mohammad Rostami, Melinda Chang, Shrikanth Narayanan
In IEEE International Conference on Image Processing (ICIP), 2022
@inproceedings{avramidis2022automating,title={Automating Detection of Papilledema in Pediatric Fundus Images with Explainable Machine Learning},author={Avramidis, Kleanthis and Rostami, Mohammad and Chang, Melinda and Narayanan, Shrikanth},booktitle={IEEE International Conference on Image Processing (ICIP)},pages={3973--3977},year={2022},doi={10.1109/ICIP46576.2022.9897529},organization={IEEE},}